Gary Cooper Henry Louis 'Lou' Gehrig
Teresa Wright Eleanor Twitchell
Babe Ruth Babe Ruth
Walter Brennan Sam Blake
Dan Duryea Hank Hanneman
Elsa Janssen Christina 'Mom' Gehrig
Ludwig Stössel Henry 'Pop' Gehrig
Virginia Gilmore Myra Tinsley
Bill Dickey Bill Dickey
Ernie Adams Miller Huggins
Pierre Watkin Mr. Twitchell
Harry Harvey Joe McCarthy
Bob Meusel Robert W. Meusel (as Robert W. Meusel)
Mark Koenig Mark Koenig
Bill Stern Bill Stern
Addison Richards Coach
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